Allies[]
With All The Turtles: Raph usually has some sort of love-hate relationship with his brothers. Then again, all siblings do. His general approach is tough love. He often gets into quarrels with his brothers, and is easily fustrated with Leo's position as a leader, Donnie acting like a know-it-all, and Mikey's lack of maturity. His brothers, on the other hand, can't stand his temper. Despite all that, Raph loves his brothers as much as they love him, and he will go to great lengths to fiercily protect them from any sort of harm, especially his two youngest brothers Donnie and Mikey. He will always back them up in a fight, especially Leo. Raphael openly admitts that he is willing to risk his own life, but never the lives of his brothers.
Leonardo: There's usually a lot of tension between the two oldest brothers out of the four, as Leo acts as if he is better than Raphael, and Raphael has made it his personal goal to prove him wrong. The two also debate over other things, namely the Karai situation. Raph can tease Leo with ease; however, for Leonardo, it is difficult for him to tease back, as he loves his brother, and has less of a 'tough love' approach. Their sibling rivalry tends to put a strain on their relationship and at times puts the team at risk. The reasons why Raph doesn't accept his big brother as a leader is because he views himself the strongest, as seen in "Rise of the Turtles”. Despite the arguing, Raph seems to be very close with Leo and they do love each other very much. Raph did agree that Leo and him are the strongest fighters. He even comforted Leo when his heart was broken by Karai. As Raph doesn't always trust Karai as Leo wishes to, he does inform Leo that his attempts to get her on her side, esspecialy the one where Leo tries to reveal the fact that she's Splinter's biological daughter to her, will become hopeless. As seen in "I,Monster" Raph tends to look to Leo for answers, aside from Donnie. Raph was really worried when Leo get hurt so badly in The Invasion. He has maintained a vigil over Leo until he awoke.
Donatello: Raph loves Donnie as a brother, but like the rest of his brothers, gets very agitated when Donnie starts acting like a know-it-all and talks in "super-smart techno-babble". Raphael likes to make fun of Donnie as a geek, or for his crush on April. Despite this, Raph doesn't tease Donnie nearly as much as he does Leo or Mikey. Raph and Donnie are complete opposites when it comes to thinking; Donnie often thinks too much and Raph often doesn't think enough. Donnie is Raph's younger brother, even though Donnie's taller than him. He seems to have little respect for Donnie (and Mikey) as a fighter. This is seen in "Mouser Attack!" when Raphael (and Leonardo) kept labling Donnie and Mikey 'the B-Team' or when he declined Leo's idea to contact Mikey and Donnie for help when the mousers attacked them. It wasn't until the near end and dubbed him and Mikey the A Minus-team (which they were fine with, as it was as good as they were going to get from Raph). Despite all this, Raph loves Donnie and willing to do anything for him. He has complemented Donnie on some of his findings and when he turned Leatherhead's subway car into "The ShellRazor," Like with all his brothers, Raph is protective of Donnie, and Donnie is willing to assist him the best he can in battle.
Michelangelo: Raph is not that close with Mikey. He often gets irritated when Mikey says or does something dumb or silly. Raph is seen beating Mikey up when he erupts. Despite that, he is seen to guiding his baby brother to somewhat the dark side when it comes to villains like in Never Say Xever where he told Mikey not to apologize for dropping Bradford, and Mikey obeyed. He and (sometimes Leo) seem to have little respect for Mikey (and Donnie) as a fighter. This is seen in "Mouser Attack!" when Raphael (and Leonardo) kept labling Donnie and Mikey 'the B-Team' or when he declined Leo's idea to contact Mikey and Donnie for help when the mousers attacked them. It wasn't until the near end and dubbed him and Mikey the A Minus-team (which they were fine with, as it was as good as they were going to get from Raph), as he playfully gave Mikey a nuggie. Despite all that, he cares a lot about Mikey and gets furious, like the other two, everytime Mikey gets hurt by an enemy (as seen in "I think his name is Baxter Stockman"). He was also the first to show major concern when he realized Mikey was in danger in New Friend Old Enemy. He was extremely concerned when Mikey got hurt during the battle with Snakeweed, even giving him a hug. In Coackroach Terminator when Mikey was kidnapped by Spy-Roach (when playing bait), Raph decided to put his fears aside to go save Mikey. Raph, along with Donnie and Leo, even threatened Leatherhead to stay away from him in It Came From The Depths. Raph seems to be very close with Mikey, and is as protective of him as much as he is with the others as seen in Invasion of the Squirrelanoids when he rescues Mikey from drowning with the Squirrelanoids. In The Invasion, Raph and Mikey really show off their love and feelings for each other. When the other was sad or scared he would give him a hug or tell him something comforting.
Master Splinter: Raph loves Master Splinter as a father and a sensei. He often tries to prove to him that he's better than Leo. Splinter is aware of Raph's temper and often must give him a guiding hand to keep his anger in check. Splinter can be hard on Raph, especially when he picks on his brothers, but never the less sees great potential in him. Splinter often wishes Raph would think more before reacting when it comes to battle. Like with all his sons, Splinter is very protective of Raph. Raphael loves his father, and showed much concern when he was taken over by the Rat King in "I, Monster." Raphael even gave Splinter a hug when Splinter came back to his senses. And in The Invasion Raph really lost temper for seeing Shredder throw Splinter to the flowing sewers and he can't do nothing.
April O' Neil: Raph and his brothers rescue April from the Kraang, but they get away with her father, Kirby O'Neil. They have interacted a little with each other, as seen in Metalhead, so they're pretty good friends. He seems to be as protective of her as he is of his brothers. This is seen in "Panic in the Sewers" where he, along with his father and brothers, were reluctant to let April spy on the foot. In that same episode, He, with Donnie's help, saved her from Dogpound when she was kidnapped. He even panicked when Mikey accidentally spilled the Kraang contaminated water on her, thinking she would disintigrate, but she didn't. Raph though, seems to like to tease her at times, as seen in "The Gauntlet" where he laughed that she was being chased by a giant pidgeon named Pete. Though he has been willing to help her out at times as seen in "Mouser Attack" where he was willing to help his brothers get April's phone back. Raphael teases his brothers less when around April, probably since she's the first human friend the turtles have and the fact she's a lady (despite his "tough guy" persona, he is respectful to women). This is seen when he got Leo and Mikey to quiet down from laughing at Donnie for getting beat up by a monkey, when April entered the room (this may also be because he knew Donnie had a crush on April, and was constantly trying to impress her). In the LEGO TMNT Raphael short, Raph defeated the Kraang to rescue April, hinting that he cares alot about her safety.
Casey Jones: Raph and Casey clashed with each other as soon as they met, and grew a quick rivalry. That rivalry dissolved into friendship when they were forced to work togther, and actually saved each other from life-threatening danger. The two of them proved to be so much alike that Donnie stated that now they had two Raphael's now.
Karai: He hated Karai from the first moment he saw her. He did try to warn Leo about her, though he did mention to him that he understood how Leo saw Karai was hot (in an evil kind of way). Raph trusts Karai the least considering she's Shredder's daughter, whether adopted by Shredder or not, even telling Leo that their chances of her being on their side wasn't really big, esspecially if it includes revealing the fact that she's Splinter's biological daughter, Miwa. But it looks like Raph is caring about her since Karai was on their side now that she has accepted that Splinter as her birth father. In Serpent Hunt he even saved her from being shot by Ivan Steranko.
Spike / Slash: Spike is Raph's pet (un-mutant) turtle whom he adores. Raphael rescued Spike after he had been flushed down a toilet, and into the sewers. Raphael has a soft spot for Spike which is "adorable" according to Mikey, and often talks to him about his feelings in private. Spike is very important to Raph, as he needs Spike as a sounding board for his inner thoughts and feelings. He can't reveal his feelings to his brothers (lest he ruin his 'tough-guy' reputation) so he shares them with Spike. Spike is an excellent listener and always listens to Raph, even if he can't speak. Spike seems to love Raph as much as Rah loves him, esspecially since Raph takes care of him and feeds him his favorite food, lettuce leaves. When Spike mutates into Slash however, that bond is broken, when Slash tried to destroy Raphael's brothers one by one, in order to grant Raph's wish for a free life. Raph does not approve of Slash's actions, and makes a dangerous foe out of his former pet. In Metalhead Rewired Slash saves Raph from a Kraang sneak attack, showing that, even after their fight, he still cares for Raph. Afterwards, when Slash new partner, Newtralizer, goes off the deep end, the rift between master and former pet is healed, but Slash goes out on his own, seeking his own purpose in life. Raph hopes that someday, Slash will finally return.
Pigeon Pete: Raph is shown to have little tolerance for Pete, even seeing him as "the most useless mutant ever".
Mona Lisa: Raph falls in love with Mona when she gave him an uppercut attack saying that he has never been hit like that before and he liked it.
Enemies[]
Shredder: When Raph and Shredder met as soon as they saw each other, they knew they were enemies. Raph hates Shredder (not only for trying to kill him - in Raph's mind that is probably not so bad), but for harming his brothers, and everything he's done to his father, Splinter. He was the first turtle to suggest that they take out Shredder at the pier in Enemy of My Enemy.
Fishface: Out of all the villains, Raph hates Montes the most. He fights him every chance he gets. In Baxter's Gambit, they work together pretty well, and seem to be alike due to their aggression and wiliness to fight til the end. Fishface even tells Raph about his past. Despite their alikeness, Raph and Fishface are still in a way opposites as Raph fights for those he loves and to protect people while Fishface fights to get what he wants or to please Shredder. In Mikey gets shellacne before Raph could get seriously hurt by Rahzar, Fishface tackles him into a fight. Fishface could've saved him by choice but didn't let it show. Since he wants the pleasure of destroying Raph himself.
Stockman-Fly: Raph and Stockman interacted very little, even when Raph got pleasure by throwin him in the trash.
Rocksteady: Raph hates Rocksteady especially after he was hit on the forehead by Steranko's knuckledusters for foiling his aim at Karai. Despite their alikeness, Raph and Rocksteady are still in a way opposites as both can be judgmental.
Bebop: Raph often annoys Bebop by making fun of his high-tech suit.
Spy-Roach: Due to his intense fear of cockroaches, Raph both hates and fears Spy-Roach. Spy-Roach also hates Raph, because he tried to kill him when he was a normal cockroach. During the whole episode Cockroach Terminator, Spy-Roach stopped at nothing to kill Raph using Raph's fear of him to his advantage, along with his mutation. Raph spent the whole episode trying to get away from him, but was forced to get over his fear, when Spy-Roach kidnapped Mikey, in hopes of luring Raph out. Raph managed to save Mikey and faced his fear of Cockroaches, fighting the mutant roach, and destroyed him with the drill the Kraang were going to use to drill into the earth's core.
Spider Bytez: Raph and Vic really hated each other from the moment they first met. Raph despises him because Vic insulted not only him, but also his brothers, and took pleasure in tormenting and insulting Raphael, because he got a reaction out of him. When he caught the turtles on tape, Raph wanted to really break his face, but his temper became a problem for the team. Vic hates him because he and his brothers broke his phone and satalite dish. He also blackmails them into giving him a million dollars for the tape. Vic also blames Raph and his brothers for becoming a mutant spider, and attempted to kill the four boys, starting with Raph's brothers, but Raph managed to control his temper and defeat him. For some reason, Spider Bytez calls them kung fu frogs. Spider Bytez is one of the 3 villains that Raph hates, the others are Spy-Roach, Fishface and Rocksteady. In a way...Spider Bytez and Raph are alike, due to their temper and being nasty twoards others, the only difference is Vic is just plan nasty and will do anything to get what he wants while Raph just has a slight temper but is willing to fight for the people he loves.